Our long term research interests are:

(1) Prediction and modeling of drug-discovery-related proteins, such as GABA receptors, SARS coronavirus proteinase, apoptosis proteins, membrane ion-channels, G-protein-coupled receptors, adhesion proteins, growth hormones, tau protein kinases, GFAT (for diabetes), b-secretases (for Alzheimer disease), antifreeze proteins, dopmin receptors, as well as those targeted for finding drugs against various infectious diseases and CNS diseases.

(2) Development of various novel methods in bioinformatics and proteomics, such as predicting HIV protease cleavage sites, protein subcellular location, membrane protein type, signal peptide, protein quaternary attribute, enzyme family classes and sub-classes, enzyme active sites, protein tight turns, and protein structural classes.

(3) Introduction of physical conceptions to elucidate various marvelous dynamic mechanisms in biomacromolecules, such as allosteric transition, cooperativity effects, and intercalation between DNA and drugs.

(4) Development of graphical rules for studying enzyme kinetics and protein folding dynamics.

(5) Investigation of protein structural characters and revelation of their origin.

(6) Introduction of diagrammatic approach for condon usage analysis.

(7) Investigation of internal collective motion of biomacromolecules and its biological functions.